Orthokine is an antilogous concept that is used for the treatment of arthritis and spinal disorders. Osteoarthritis, the loss of cartilage in the joint has many causes. The factors like being overweight, predisposition, heavy load by work, etc are the main causes for osteoarthritis. In western countries there is about ten percent of the populations suffering from osteoarthritis. A protein named interleukin-1 (IL-1) plays a crucial role in the development of osteoarthritis and destruction of cartilage. Osteoarthritis patients will have too much IL-1 present in their joints. IL-1 is a most prominent active agent which damages the cartilage and so the natural shock absorber in the joint loses its function.
The therapy of osteoarthritis is done using IL-1 blocker which is known as interleukin-1 receptor antagonist (IL-1Ra). IL-1Ra is anti-inflammatory, reduces pain and also protects the cartilage. The orthokine procedure is done by taking blood from the patient using a special syringe called orthokine syringe. The orthokine syringe is approved in the EU and Australia. The blood taken from the patient is an antilogous injection solution and it is called as orthokine serum. The Interleukin-1 receptor antagonist is naturally present in the blood. However, with the production of orthokine, it is produced and extracted in higher concentrations. So, to increase the concentration of IL-1Ra, blood samples are taken from the arm vein using special EOT syringe. The glass beads in the syringe induces the blood cells to synthesize increased amounts of protective proteins. The temperature of 37'c in the incubator is the optimum environment for protein synthesis.
During incubation, the white blood cells present in the bloods are stimulated immediately to produce IL-1Ra and other anti-inflammatory and regenerative proteins. They are increased in concentration and the "Antilogous Conditioned Serum"(ACS) is injected into the joint. A centrifuge separates the blood clot from the amber serum, containing the protective proteins in high concentration. The protective protein IL-1Ra displaces the damaged protein IL-1 and the inflammation process is blocked. Subsequent therapy includes about six injections that will be given once or twice weekly.
The orthokine procedure is used throughout the world by orthopaedic surgeons and rheumatologists. This procedure cannot be compared to treatments using the patient's own blood that is often used in alternative medicine. In Germany alone there are over 20,000 patients have been treated by this orthokine treatment. The advantages of this treatment is, pain in the joints will be reduced, improves the joint function and mobility and the continuing process of cartilage destruction will be blocked. This treatment is very efficient and safe.